Thalia A-SUP keep the HHF clean as to sequential selectable fluid velocities  

Thalia is an Alternating-Single-Use-Pump = A-SUP. A reciprocating fluid exchanger which give CellRetention Perfusion-SUB package its unique properties.

The desktop size Clotho, Lachesis and Atropos Drive Units gives the LASER guided Thalia A-SUP its groundbreaking performance. Clotho software measures via the LASER sensor the position of the free-flowing elastic diaphragm in real-time. The result is an Air-Operated-Diaphragm-Positive-Displacement (AODPD) Single-Use-Pump. Allowing end-user to choose freely volume to be conveyed and velocities to clean the HFF regularly.

Scalable - YES - check out the spec table

Thalia innovative technical functionality

• Thalia keep the HFF (Hollow-Fibre-Filter) clean, free from fouling issues by programmable sequential selectable high fluid velocity flushing out debris securing optimum HFF performance and secure process time with a single HFF
  
• Thalia exchanges a chosen specific fluid volume ranging with from 0 to +10 m/sec fluid velocity through the HFF module from feed inlet to retentate outlet independent of HFF pressure drop
• The Alternating-Single-Use-Pump (A-SUP) feature a position controlled free-floating elastic silicone diaphragm - no motors, no gearboxes, no rollers, no valves - required
• Thalia do not convey fluid as a typical pump - like a centrifugal pump – but exchange forth and back the desired, programmed fluid volume and velocity (m/s) at the desired Beat-per-Minute (BpM) and stroke volume (SV)
• Thalia A-SUP is connected directly to the Hollow-Fiber-Filter (HFF) module
• Thalia features the re-usable LASER sensing diaphragm position giving outstanding performance and accuracy
• The high precision LASER sensor measures constantly and accurate the position of the diaphragm, allowing Clotho software to display desired conditions for exchanged broth volumes and velocities in real-time
• Thalia can facilitate and control the TMP, Trans-Membrane-Pressure in a loop with just one external pressure sensor

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Thalia range M80 M200

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dual Thalia M140 + LASER

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Thalia M80 to M200 on SS feet

Photo at left show scalability with a range of LASER sensors in front. Centre photo show Thalia M100 and angle with the red LASER sensor inside the red support. Right photo show the range M80 to M200.

Ground breaking user features are:

• Thalia handle fluids = liquids and gases in any mix
• Thalia easily sucks fluids from low arranged bioreactors or deep tubes
• Thalia is a metering pump = PD (Positive Displacement) pump = 1% accurate liquid mass-flow detection
• Thalia do NOT need any mass-flow sensor to measure mass-flow - Thalia measures constantly mass-flow in real-time
• Thalia do NOT need frequent (or any) calibration like peristaltic pumps
• Thalia do NOT loose nano size silicone particles to the fluid like peristaltic pumps
• Thalia do NOT create shear forced destroying mammalian cells
• Thalia is both an Alternating and gentle Pulsating fluid pump allowing new dynamics in avoiding HFF deposits, fouling via accurately controlled volumes and velocities passing through the HFFs lumen

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Thalia M100 + M140 + LASER

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Double Thalia M200

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M200 with HFF

Left photo show Thalia M100 and M140 each with HFF and on Stainless-Steel-Foot (SSF) for good weight balance. Centre photo M200 with the 3” TRI flange HFF on the A-SUP body and visible the red LASER support and the LASER sensor. Photo to the right show the ball shaped M200 A-SUP with 3” TRI-flange connection to 3” HFF.

The basics in operation is copied from the human heart functionality

• Cardiac Output (CO) = total pumped volume, SUP capacity, mL/min (CO = BpM x SV)
• Beats-per-Minute (BpM) = ranging 0 - 30 BpM, SUP diameter/stroke/volume depending
• Stroke Volume (SV) = programable from 0 - 100% of SUP capacity
• Velocities ranging very low to more than 10 m/sec

Check out under Support and Download