Hamilton biomass Single-Use-Sensor
Bio-mass and viability is important. Capacitance sensor technology measures equally well adherent or suspension type of mammalian cells during cultivation. Typical range for mammalian is 105 cells/ml to 109 cells/ml.
The latest Hamilton Incyte-W-ARC Single-Use-Sensor technologies integrated in various rigid plastic vessels ranging from size 3.2 liter and up. The Hamilton capacitance SUS patch is integrated into a side wall, the ARC signal-converter is connected mechanically to the outside vessel wall and electrically connected to Cronus-PCS Sipylus pre-amplifier for signal processing. https://cronus-pcs.com/products/niobe-sensors/sipylus/
The bio-mass sensor system sense total capacitance measured in pico Farad/cm with 2-3 % accuracy. Viable Cell Density (VCD) system monitors the volume of live cells typically 18 µm in size. The principle is expressed in permittivity as the system can detect the response of cells with intact membranes. Cell fragments, particles and gas bubbles are not measured.