Upgraded 250 ml P-SUB for Modular PCS
- SUBmerged™ HFF (Hollow-Fibre-Filter) eliminates dead volumes
- Direct coupled HFF to inverted innovative LASER guided Thalia diaphragm Single-Use-Pump eliminates shear stress, cell accumulation and fouling
CellRetention-250 ATF unique arrangement integrates all 3 components in one unit for very easy Modular PCS installation. Modular takes care of agitation, aeration, pH, DO and media. Clotho takes care of ATF perfusion and protects the HFF.
Clotho Drive Unit integrates pressures, vacuum, volume sensing eliminating the need for external sensors for TMP, pressure drop, flow measurements. Clotho process software controls accurately the programmable stroke volume, number of strokes, the allowed pressure drop along the HFF for fully automatic harvest and fully selectable fluid velocity for the sequential lumen cleaning eliminating HFF blockage.
Left photo show next to the Clotho drive unit two ATF P-SUBs integrating SepraPor HFF and in front the LASER guiding Thalia SUP unique performance. The right photo shows the 250 ml ATF P-SUB installed in the Modular PCS. Note there is NO flow restricting Luer-Loc in the broth path for lowest possible shear forces.
- We combine the 250 ml batch SUB with SepraPor HFF and Thalia SUP for trouble free installation and operation.
- Thalia™ LASER guided Single-Use-Pump controlled by outstanding Clotho™ software
- Alternating broth volume and velocity fully programmable, accurately measured and fully repeatable – no process guessing
- SUBmerged™ and Direct-Fit HFF eliminating shear stress caused by Luer-Loc™ fittings -
- The complete and pre-assembled P-SUB packed in dual film bags and precision irradiated – forget the autoclave and hood
- Desired hose and lenght for permeate and media addition as needed
It is possible to operate the 250 ml in Modular the old fashion way – yes, but …
Then being faced with cell accumulation, huge dead volumes – though NO fouling as solved by Clotho and Thalia.
IPR covered by: CellRetention, CerPhragm, SUBmerged.