Thalia™ keep the HFF clean with sequential selectable fluid velocities
Thalia is an Alternating-Single-Use-Pump = A-SUP. A reciprocating fluid exchanger which give CellRetention Perfusion-SUB package its unique properties. And when Thalia is integrated with SepraPor into the P-SUB and thus become SUBmerged gives a number of unique benefits.
The desktop size Clotho, Lachesis and Atropos Drive Units gives the LASER guided Thalia A-SUP its ground-breaking performance. The software measures via the LASER sensor the position of the free-flowing elastic diaphragm in real-time. The result is an Air-Operated-Diaphragm-Positive-Displacement (AODPD) Single-Use-Pump. Allowing end-user to choose freely volume to be conveyed and velocities to clean the HFF regularly.
Scalable - YES - check out the spec table
|
Thalia A-SUP name / size |
TM50 |
TM80 |
TM100 |
TM140 |
TM200 |
TM300 |
|
Availability as part of a P-SUB |
|
|
|
|
|
|
|
Layout, number of diaphragms |
Single |
Single |
Single |
Single |
Single |
Single |
|
Diaphragm diameter, mm |
50 |
80 |
100 |
140 |
200 |
300 |
|
Stroke Volume, SV, mL, 100 % stroke |
30 |
50 |
200 |
500 |
2,400 |
6,000 |
|
Cardiac Output, CO range, max mL/min |
400 |
900 |
3,000 |
5,000 |
19,000 |
30,000 |
|
Beats-per-Minute, BpM |
0-20 |
0-18 |
0-15 |
0-10 |
0-8 |
0-5 |
|
Choose from one of various feed connections |
HFF integrated |
HFF integrated |
HFF integrated |
HFF integrated |
HFF integrated or Tri 3” |
Tri 4-1/4” |
|
Comparable to |
|
ATF1 |
ATF2 |
ATF4 |
ATF6 |
ATF10 |
|
Drive Unit |
Clotho |
Clotho |
Clotho |
Clotho |
Lachesis |
Atropos |
Thalia innovative technical functionality
- Thalia keep the HFF (Hollow-Fibre-Filter) clean, free from fouling issues by programmable sequential selectable high fluid velocity flushing out debris securing optimum HFF performance and process time with a single HFF
- Thalia exchanges a selectable specific fluid volume ranging with from 0 to >10 m/sec fluid velocity through the HFF module from feed inlet to retentate outlet independent of HFF pressure drop. The only pump able to offer selectable pulsating velocity to flush out debris.
- The Alternating-Single-Use-Pump (A-SUP) feature a position controlled free-floating elastic silicone diaphragm - no motors, no gearboxes, no rollers, no Mass-Flow-Sensor required
- Thalia do not convey fluid like a centrifugal pump – but exchange forth and back the desired, programmed fluid volume and selectable velocity (m/s) at the desired Beat-per-Minute (BpM) and stroke volume (SV)
- Thalia A-SUP from size TM50 to TM200 is integrated with the Hollow-Fiber-Filter (HFF) module eliminating excessive hoses, Luer-Loc and TRI-clamps
- Thalia features the re-usable LASER sensing diaphragm position giving outstanding performance and accuracy
- The high precision LASER sensor measures constantly and accurate the position of the diaphragm, allowing Clotho, Lachesis, Atropos software to display desired conditions for exchanged broth volumes and velocities in real-time
- Drive Units facilitate and control the TMP, Trans-Membrane-Pressure
Photo at left show scalability with a range of integrated Thalia and SepraPor. Centre photo show angled Thalia TM100 and TM140 with the red LASER sensor inside the red support. Right photo show the range TM80 to TM200.
Ground breaking user features are:
- Thalia handle fluids = liquids and gases in any mix
- Thalia easily sucks fluids from low arranged bioreactors or deep tubes
- Thalia is also a metering pump = PD (Positive Displacement) pump = 1% accurate liquid mass-flow detection
- Thalia do NOT need any mass-flow sensor to measure mass-flow - Thalia measures accurately and constantly mass-flow in real-time
- Thalia do NOT need frequent (or any) calibration like peristaltic pumps
- Thalia do NOT loose nano size silicone particles to the fluid like peristaltic pumps
- Thalia do NOT create shear forces destroying mammalian cells
- Thalia is both an Alternating and gentle Pulsating fluid pump allowing new dynamics in avoiding HFF deposits, fouling via accurately controlled volumes and velocities passing through the HFFs lumen
Left photo show short SUBmerged kits Thalia TM100 and TM140 each with 300 mm long SepraPor HFF. Center photo long SUBmerged kits Thalia TM100 and TM140 each with 600 mm long SepraPor HFF. Tiny LASER sensor seen as well. Photo to the right show the ball shaped TM200 A-SUP with SepraPor OD76 mm Direct-Fit connection.
The basics in operation is copied from the human heart functionality
- Cardiac Output (CO) = total pumped volume, SUP capacity, mL/min (CO = BpM x SV)
- Beats-per-Minute (BpM) = ranging 0 - 15 BpM, SUP diameter/stroke/volume depending
- Stroke Volume (SV) = programable from 0 - 100% of SUP capacity
- Velocities ranging from very low to more than 10 m/sec