Revolutionizing ATF perfusion SUB
Old fashion desktop ATF perfusion systems depend on quite a long fluid path from bioreactor passing hoses and connectors before broth reach the HFF and the pump.
What about re-invented ATF system avoiding fouling, dead volume and shear stress?
SUBmerge SepraPor HFF into SUB with inverted Thalia diaphragm pump on top
- Angled inverted LASER guided Thalia diaphragm pump copying the mammalian heart are designed to master broth velocity from low for harvest to sequential high for HFF cleaning.
- SepraPor Hollow-Fiber-Filter (HFF) SUBmerged into the SUB broth eliminate dead volume and shear stress. Inverted Thalia pump by design cannot collect and kill cells.
- Single-Use-Bioreactor (SUB) with Single-Use-Sensor (SUS) and hoses as needed.
- For agitation the SUB is driven from head plate and angled Thalia offer needed space
- Thalia operated by Clotho Drive Unit altering accurately stroke volume, number of strokes, and very important fluid velocity. DeltaP along the HFF are measured by Clotho allowing fully automatic harvest and selectable instant high fluid velocity for the sequential cleaning eliminating HFF blockage / fouling.
Check out - CellRetention-3-submerged
Kind regards from
Per Stobbe