Re-Invented Perfusion-Single-Use-Bioreactor (P-SUB)

                Benefits of the ATF-SUBmerged™ and TFF-Integrated are:

  • avoid HFF fouling –  freedom to select any broth velocity flushing out debris from inside the HFF by LASER guided Thalia diaphragm pump
  • avoid dead volumes – skip hoses, fittings - SUBmerged SepraPor HFF integrated with Thalia diaphragm pump eliminates dead volumes
  • avoid cell death - innovative inverted Thalia pump arranged above the SUBmerged SepraPor so the Thalia pump cannot accumulate cells 
  • reduce shear stress – eliminating hoses, fittings and SUBmerge the cartridge into the broth reduces shear stress to lowest possible
  • SUBmerged - HFF cartridge directly in the broth inside the SUB - no hoses, fittings needed = simplified, reliable and ready to use

3 Liter SubmergedTerry Present Modula Kit250 Ml ATF P SUB For Modula 2ATF 500 Ml Clotho + HarmoniaMini P SUB ATF Bioblu 2Submerged 13 Liter + Motor

Fully assembled SUBmerged (series 31) with Vessel Volume (VV) ranging 250 ml for the Modular or 0.3 for DASbox or scalable further from 0.5 - 3 - 6 - 13 up to 30 liter rigid plastics. As Thalia and SepraPor is scalable PerfuseCell will go further up in P-SUBmerged volume when needed.

The industry is facing the well known problem of cleaning and keep the Hollow-Fiber-Filter clean in perfusion processes. Lets face it - none of the existing technologies gave any of us viable solutions. A better technology and reliable platform is required.

The latest invention - P-SUBmerged - features LASER guided diaphragm Single-Use-Pumps named Thalia. Specifically designed to alter accurately broth velocities between many gentle harvest cycles to a few fast cleaning cycles flushing out HFF fouling. 

              PerfuseCell twin P-SUB portfolio - a new era in perfusion 

CellRetention™ ATF-SUBmerged™ combines the Thalia Alternating-Single-Use-Pump (A-SUP) and SepraPor® Hollow-Fiber-Filter (HFF) cartridge, Hamilton Single-Use-Sensors with the SUB (series 31).

CellMembra™ TFF-INTEGRATED™ unify the scalable Clio OneWay-Single-Use-Pump (O-SUP) and SepraPor® Hollow-Fiber-Filter cartridges, multiple Single-Use-Sensors with the SUB (series 30).

               Check out P-SUB product matrix under support 

 

Drive Units Clotho and Lachesis (series 35) for Thalia and Clio incorporate ground breaking high-tech software. Any of PerfuseCell P-SUBs runs perfect stand-alone on series-35 Drive Units or on Cronus-PCS package supported by Lucullus or DeltaV.

 

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