Parallel mini volume ATF 250ml P-SUB for Modular
Traditional desktop ATF depends on quite a long fluid path from bioreactor passing hoses before reaching the HFF and to the diaphragm pump on the lab table.
Avoid unwanted dead-volume in said fluid path and shear stress passing Luer-Loc connections.
The left photo shows heavily customized 250 ml SUB integrating a SepraPor HFF “SUBmerged” deep into the SUBs broth volume. On top of SepraPor the inverted Thalia LASER guided diaphragm pump avoid cell collection.
The right photo illustrates a compact parallel installation on Modular simplified by a fully loaded pre-assembled single-use set of ATF P-SUBs.
The Clotho diaphragm pump Drive Unit and software controls accurately the stroke volume, number of strokes, and very important fluid velocity of the Thalia pump.
Pressure drop along the Hollow-Fibre-Filter (HFF) are measured by Clotho allowing fully automatic harvest and selectable instant higher fluid velocity for the sequential HFF cleaning eliminating HFF blockage or fouling.
Kind regards from
Per Stobbe