The Thalia alternating Single-Use-Exchanger

Thalia fluid exchanging features

Thalia is an alternating (pulsating, bi-directional, reciprocating) fluid exchanger and part of the CellRetention Perfusion-SUB package.

The super compact Clotho Drive Unit gives Thalia its unique performance. Clotho measures via the Laser sensor accurately in real-time the position of the free-flowing elastic diaphragm. The result is an Air-Operated-Diaphragm-Positive-Displacement (AODPD) Alternating-Single-Use-Exchanger (A-SUE) with non-parallel performance and capabilities.

Thalia technical functionality:

The Alternating-Single-Use-Exchanger (A-SUE) feature a position controlled free-floating diaphragm
Thalia do not convey fluid as a typical pump – but exchange forth and back the desired, programmed fluid volume
Thalia A-SUE is integrated with, connected directly to the Hollow-Fiber-Filter (HFF) module
Thalia feature the re-usable Laser sensor for outstanding performance
The high precision Laser sensor measures constantly and accurate the position of the diaphragm, allowing Clotho to display desired exchanged broth volumes and velocities in real-time
Thalia exchange any fluid volume ranging within its size and from 0 to +10 m/sec broth velocity through the HFF module

Thalia-30 and Thalia-100

LS-100 for Thalia with Laser

Thalia-100 on LS-100

Photos illustrate Thalia-30 and Thalia-100. The black “Laser Support Thalia” (LST-100) supports both the SUE cell and the red Laser sensor.

User features are:

Thalia handle fluids = liquids and gases in any mix
Thalia easily sucks fluids from low arranged bioreactors
Thalia is a metering pump = PD (Positive Displacement) pump = 1% accurate liquid mass-flow
Thalia A-SUE do NOT need any mass-flow sensor to measure mass-flow
Thalia do NOT need calibration like peristaltic pumps
Thalia do NOT loose nano size silicone particles to the fluid like peristaltic pumps
Thalia is both an Alternating and Pulsating fluid exchanger allowing new dynamics around avoiding HFF deposits via accurately controlled volumes and velocities

Thalia-100 in foot with red Laser

Sanitary for Thalia-100

Thalia-100 and T06-P20U HFF

Sanitary couplings currently used for connecting Thalia to the HFF.

Thalia Alternating-Single-Use-Exchanger (A-SUE) is unique and absolute latest and most advanced AODPD in the market for biopharma purposes. Thalia specifications:

Stand-alone product, cell names	Thalia-30	Thalia-100	Thalia-300
Layout, number of diaphragms	single	single	single
Diaphragm diameter, mm	62	80	100
Diaphragm stroke, mm	25	39	46
Stroke Volume, SV, mL, 100% stroke	34	100	500
Cardiac Output, CO range, mL/min (recommended)	0-1.000	0-2.000	0-4.000
Beats-per-Minute, BpM, max	0-35	0-20	0-15
Typical hose connection, ID/OD mm	4/8	8/12	12/18

The basics in operation is copied from the human heart functionality:

Cardiac Output (CO) = total pumped volume, SUE capacity, mL/min (CO = BpM x SV)
Beats-per-Minute (BpM) = ranging 0 - 30 BpM, SUE diameter/stroke/volume depending
Stroke Volume (SV) = programmable from 10 - 100% of SUE cell specification