Scalable and very compact Continuous-Processing-SUB system's
The CellCore™ concept support mammalian cells at Continuous-Processing cultivation at constant high cell density under steady state conditions. CellCore provides integrated pump technologies insuring specialized dynamic flow through a parallel array of porous envelopes. The cells are maintained in a proprietary porous matrix / scaffolding in the envelopes. Properties of the scaffolding, such as fiber diameter, porosity and pore size, are specified to fit individual culture formats with some applications supporting densities beyond 150 million cells/ml.
Features for CellCore concept:
- Suspension as well as adherent cells, immobilized in the cell retention cavities with an average of 0.05 nano liter per cell per day media exchange rate
- Operates under steady-state conditions for weeks or months with continues expression of product
- The fixed packed-bed system eliminates gradients in primary and secondary metabolite and supports cultivation of both adherent and suspension cell lines
- Selectable in a 1:1,000 scalable platform – lab scale to pilot scale – all desk-top size
All pre-assembled, pre-packed, single-use and ready for easy use.
Take one step deeper into each of the variant.
Patent applied for CellCore™ and CerPhragm™.